Research

Biochemically dynamic host continuously challenged by numerous fast evolving microbes. These microbes perturb the host immune homeostasis through hijacking or skewing cellular biochemical pathway for its own benefit. Host innate immune system is front shield to defend invasion and propagation of invading microbes through biochemical mediators generated via complex network of cell signaling. These signaling pathways are tightly regulated by various molecular switches. Our major interests is to understand these immune regulatory switches in regulation of signaling flux in various infection and also to understand the interplay and intricacies among molecules of host and microbe and its role in disease outcome or clearance of pathogen. Our questions are:

1. Investigation of influence of extrinsic and intrinsic factors on viral and/or bacterial infection for discovery of better strategies to reduce the pathogen burden.

2. What are the host post-transcriptional regulators of innate immunity and its cross-talk with different viral genome for development of RNA based therapeutics.

3. We are also investigating the interrelation among virus, antiviral pathways and cancer to develop oncolytic viruses for therapeutic purpose.