OBCL: Organic and bioconjugate chemistry LABoratory
Publications
Chemical technology principles for selective bioconjugation of proteins and antibodies, Chauhan, P.; Ragendu, V.; Kumar, M.; Molla, R.; Mishra, S. D.; Basa, S.; Rai, V. Chem. Soc. Rev. 2024, 53, 380-449. (Themed collection: 2023 Pioneering Investigators)
Ordered immobilization of serine proteases enabled by linchpin directed modification platform, Rawale, D. G.; Gupta, M.; Thakur, K.; Ragendu, V.; Rai, V. Chem. Commun. 2024, 60, 7168-7171.
Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice, Bauri, R.; Bele, S.; Edelli, J.; Reddy, N. C.; Kurukuti, S.; Devasia, T.; Ibrahim, A.; Rai, V.; Mitra, P. Am. J. Physiol. Cell Physiol. 2024, 327, C74-C96.
Protein-protein interaction in multicomponent reaction enables chemoselective, site-selective, and modular labeling of native proteins, Molla, R.; Joshi, P. N.; Reddy, N. C.; Biswas, D.; Rai, V. Org. Lett. 2023, 25, 6385-6390. (Invited contribution: OL Virtual Special Issue on Chemoselective Methods for Labeling and Modification of Peptides and Proteins)
DisINtegrate (DIN) theory enabling precision engineering of proteins, Chauhan, P.; Ragendu, V.; Mohan, K.; Molla, R.; Unnikrishnan, V. B.; Rai, V. ACS Cent. Sci. 2023, 9, 137-150. (Invited contribution: Principles to enable hypothesis-driven research in the field - DIN theory could serve bioconjugation in the same way retrosynthetic analysis benefits organic synthesis)
Evolution of chemistry for precision engineering of proteins, Ragendu, V.; Kumar, M.; Molla, R.; Thakur, K.; Chauhan, P.; Rai, V. AsiaChem 2023, 3, 124-135. (Chemistry in India special issue)
Traceless cysteine-linchpin enables precision engineering of lysine in native proteins, Reddy, N. C.; Molla, R.; Joshi, P. N.; Sajeev, T. K.; Basu, I.; Kawadkar, J.; Kalra, N.; Mishra, R. K.; Chakrabarty, S.; Shukla, S.; Rai, V. Nat. Commun. 2022, 13, 6038.
Human behavior inspired linchpin directed catalysis for traceless precision labeling of native proteins, Thakur, K.; Sajeev, T. K.; Singh, S. K.; Ragendu, V.; Rawale, D. G.; Adusumalli, S. R.; Kalra, N.; Shukla, S.; Mishra, R. K.; Rai, V. Bioconjugate Chem. 2022, 33, 2370-2380.
Residue-specific N-terminal glycine to aldehyde transformation renders analytically pure single-site labeled proteins, Sahu, T.; Kumar, M.; Sajeev, T. K.; Joshi, M.; Mishra, R. K.; Rai, V. Chem. Commun. 2022, 58, 12451-12454.
Protein inspired chemically orthogonal imines for linchpin directed precise and modular labeling of lysine in proteins, Sahu, T.; Chilamari, M.; Rai, V. Chem. Commun. 2022, 58, 1768-1771.
Linchpin-directed precise labeling of lysine in native proteins, purification, and analysis, Bal, A.; Singh, S. K.; Kashyap, T.; Rai, V. Meth. Enzymol. 2022, 675, 383-396.
Linchpins empowers promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins, Rawale, D. G.; Thakur, K.; Pranav, S.; Sajeev, T. K.; Ramesh, A.; Adusumalli, S. R.; Mishra, R. K.; Rai, V. Chem. Sci. 2021, 12, 6732-6736.
Chemical technologies for precise protein bioconjugation enabling biology and medicine, Kumar, M.; Reddy, N. C.; Rai. V. Chem. Commun. 2021, 57, 7083-7095. (Invited Feature Article, Establishing precision engineering of proteins, 2011-2021)
Reactivity and selectivity principles in native protein bioconjugation, Ramesh, A.; Thakur, K.; Rai, V. Chem. Rec. 2021, 21, 1941-1956. (Invited article)
Single amino acid Gly-tag enables metal free protein purification, Purushottam, L.; Unnikrishnan, V. B.; Rawale, D. G.; Gujrati, M.; Mishra, S. D.; Sajeev, T. K.; Reddy, N. C.; Adusumalli, S. R.; Mishra, R. K.; Rai, V. Chem. Sci. 2020, 11, 13137-13142. (part of themed collection: "Most Popular 2019-2020 Chemical Biology Articles." Also see, Gly-Tag® purification resin @Plabeltech)
Chemoselective and site-selective lysine-directed lysine modification enables single-site labeling of native proteins, Adusumalli, S. R.; Rawale, D. G.; Thakur, K.; Purushottam, L.; Reddy, N. C.; Kalra, N.; Shukla, S.; Rai, V. Angew. Chem. Int. Ed. 2020, 59, 10332-10336. (LDM® technology: Video tutorial)
Chemical methods for modification of proteins, Reddy, N. C.; Kumar, M.; Molla, R.; Rai, V. Org. Biomol. Chem. 2020, 18, 4669-4691. (Tutoral review for organic chemists. Also see, the complete web-themed OBC issue on, "Methodology Development for Protein Modifications." Guest Editors: Professors Gonçalo Bernardes, Annemieke Madder, and Hiroyuki Nakamura; Article selected for OBC Editor's Collection, Meet the authors)
Single-site glycine-specific labeling of proteins, Purushottam, L.; Adusumalli, S. R.; Singh, U.; Unnikrishnan, V. B.; Rawale, D. G.; Gujrati, M.; Mishra, R. K.; Rai, V. Nat. Commun. 2019, 10, 2539. (Gly-Tag® technology featured in Editors' Highlights of Nature Communications)
Computationally designed antibody-drug conjugates self-assembled via affinity ligands, Gupta, N.; Ansari, A.; Dhoke, G. V.; Chilamari, M.; Sivaccumar, J.; Kumari, S.; Chatterjee, S.; Goyal, R.; Mukherjee, M.; Sarkar, A.; Mandal, S. K. Rai, V.; Biswas, G.; Sengupta, A.; Roy, M.; Roy, S.; Sengupta, S. Nat. Biomed. Eng. 2019, 3, 917-929. (News and Views: Affinity-bound antibody-drug conjugates, Nervig, C. S.; Owen, S. C. Nat. Biomed. Eng. 2019, 3, 850-851; Nature Blog)
Chemical methods for selective labeling of proteins, Rawale, D. G.; Thakur, K.; Adusumalli, S. R.; Rai, V. Eur. J. Org. Chem. 2019, 6749-6763. (Invited minireview)
Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein conjugates, Singudas, R.; Reddy, N. C.; Rai, V. Chem. Commun. 2019, 55, 9979-9982. (Maspecter® MS sensitivity boosters @Plabeltech)
Single-site labeling of histidine in proteins, on-demand reversibility, and traceless metal-free protein purification, Joshi, P. N.; Rai, V. Chem. Commun. 2019, 55, 1100-1103.
Single-site labeling of native proteins enabled by a chemoselective and site-selective chemical technology, Adusumalli, S. R.; Rawale, D. G.; Singh, U.; Tripathi, P.; Paul, R.; Kalra, N.; Mishra, R. K.; Shukla, S.; Rai, V. J. Am. Chem. Soc. 2018, 140, 15114-15123. (LDM® technology)
Aldehyde can switch chemoselectivity of electrophiles in the protein labeling, Adusumalli, S. R.; Rawale, D. G; Rai, V. Org. Biomol. Chem. 2018, 16, 9377-9381. (Themed collection: Chemical Biology and RAOBC)
Single-site labeling of lysine in proteins through a metal-free multicomponent approach, Chilamari, M.; Kalra, N.; Shukla, S.; Rai, V. Chem. Commun. 2018, 54, 7302-7305.
Site-selective labeling of native proteins by a multicomponent approach, Chilamari, M.; Purushottam, L.; Rai, V. Chem. Eur. J. 2017, 23, 3819-3823.
Chemoselective and site-selective peptide and native protein modification enabled by aldehyde auto-oxidation, Purushottam, L.; Adusumalli, S. R.; Chilamari, M.; Rai, V. Chem. Commun. 2017, 53, 959-962.
Protein self-assembly induces promiscuous nucleophilic biocatalysis in Morita-Baylis-Hillman (MBH) reaction, Joshi, P. N.; Purushottam, L.; Das, N. K.; Mukherjee, S.; Rai, V. RSC Advances 2016, 6, 208-211.
A Phthalimidation Protocol That Follows Protein Defined Parameters, Singudas, R.; Adusumalli, S. R.; Joshi, P. N.; Rai, V. Chem. Commun. 2015, 51, 473-476. (Featured on back cover)
Small Heterocycles in Multicomponent Reactions, Rotstein, B.; Zaretsky, S.; Rai, V.; Yudin, A. K. Chem. Rev. 2014, 114, 8323-8359.
Organometallic Complexes: Catalysis and Application in Protein Modification, Chilamari, M.; Rai, V. Indian J. Chem., Sec. A 2013, 52A, 992-1003. (Invited contribution to special issue on Complex Chemical Systems)
Citations @ Google Scholar
From University of Toronto
Twisted Amide Electrophiles Enable Cyclic Peptide Sequencing, Zaretsky, S.; Rai, V.; Gish, G.; Forbes, M. W.; Kofler, M.; Yu, J. C. Y.; Tan, J.; Hickey, J. L.; Pawson, T.; Yudin, A. K. Org. Biomol. Chem. 2015, 13, 7384-7388.
Bending Rigid Molecular Rods: Formation of Oligoproline Macrocycles, Scully, C. C. G.; Rai, V.; Zaretsky, S.; Burns, D. C.; Houliston, R. S.; Lou, T.; Yudin, A. K. Chem. Eur. J. 2012, 18, 15612-15617.
Synthesis of Peptide Macrocycles Using Unprotected Amino Aldehydes, Rotstein, B. H.; Rai, V.; Hili, R.; Yudin, A. K. Nat. Protoc. 2010, 5, 1813-1822.
Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics, Jebrail, M. J.; Ng., A. H. C.; Rai, V.; Hili, R.; Yudin, A. K. Wheeler, A. R. Angew. Chem. Int. Ed. 2010, 49, 8625-8629. (Featured on inside cover)
Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules, Hili, R., Rai, V.; Yudin, A. K. J. Am. Chem. Soc. 2010, 132, 2889-2891. (Highlighted in Science, C&EN and Faculty of 1000 Biology)
From IIT Bombay
Enantioselective Conjugate Addition of Dialkylphosphites to Nitroalkenes, Rai, V.; Namboothiri, I. N. N. Tetrahedron: Asymmetry 2008, 19, 2335-2338.
Effect of Achiral and Mixed Chiral Ligands in the Synthesis of γ-Nitrophosphonates via Michael Addition, Rai, V.; Namboothiri, I. N. N. Tetrahedron: Asymmetry 2008, 19, 767-772.
Cinchonine Catalyzed Diastero- and Enantioselective Michael Addition of α-Lithiated Phosphonates to Nitroalkenes, Rai, V.; Mobin, S. M.; Namboothiri, I. N. N. Tetrahedron: Asymmetry 2007, 18, 2719-2726.
A Theoretical Evaluation of the Michael-Acceptor Ability of Conjugated Nitroalkenes, Rai, V.; Namboothiri, I. N. N. Eur. J. Org. Chem. 2006, 4693-4703.
Patents
From IISER Bhopal
Linchpin directed catalysis for traceless site-selective labeling of native proteins, Thakur, K.; Rai, V. Patent application number 202221062576, November 2, 2022.
Chemoselective sensitivity booster and the process thereof, Singudas, R.; Reddy, N. C.; Rai, V. Patent application number 201921022294, June 5, 2019.
N-terminus Gly-tag specific modification, capture, and release of protein enabling metal-free protein purification, Patent application number 201921015806, April 22, 2019.
Hemiaminal-tag for protein labeling and purification, Purushottam, L.; Rai, V. International patent publication WO-2018104962-A1, June 14, 2018.
Site-selective peptides and protein labelling and synthesis of homogeneous protein conjugates, Chilamari, M.; Purushottam, L.; Rai, V. International patent publication WO-2018047197-A1, Mar 15, 2018.
Multi-functional chemical agents, and the method for protein modification, Adusumalli, S. R.; Rai, V. International patent publication WO2017158612-A1, Sept 21, 2017.
From University of Toronto
Boronic acid catalyzed macrocyclization of linear peptides, Rai, V.; Yudin, A. K. Patent application RIS 10002115, Aug 10, 2010.
A method to insert molecular fragments into cyclic molecules, Rai, V.; Hili, R.; Yudin, A. K. Patent application RIS 10002116, Aug 10, 2010.
From IIT Bombay
Asymmetric synthesis of γ-nitrophosphonates in the absence of any other chiral catalyst, Rai, V.; Namboothiri, I. N. N. Patent Application 2359/MUM/2007, Nov 30, 2007.
book chapter
Adusumalli, S. R.; Yudin, A. K.; Rai. V. Cyclic Peptides, pp 321-369, in “Natural Lactones and Lactams. Synthesis, Occurrence and Biological Activity” Ed. Janecki, T. Wiley-VCH, 2013.
conference proceedings paper
Synchronized Synthesis of Cyclic Peptides by Digital Microfluidics, Jebrail, M. J.; Ng, A.; Rai, V.; Hili, R.; Yudin, A. K.; Wheeler A. R. Proc. Micro. Tot. Anal. Sys., Chemical and Biological Microsystems Society, San Diego, CA, 2009, 1297-1299.
invited lectures
“Chemical technologies for precision engineering of proteins and antibodies,” International Conference on Science and Technology for Innovative and Sustainable Development, Mizoram University, Aizawl, June 28-30, 2023.
“Chemical technologies for precision engineering of proteins and antibodies,” Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA, May 23-25, 2023.
“Chemical technologies for precision engineering of proteins and antibodies,” Commonwealth Chemistry Congress, Trinidad and Tobago, University of West Indies, May 23-25, 2023.
“Graduation of organic chemistry for precision engineering of proteins,” Allotropes of Chemistry, ChemClub, IISER Bhopal, March 23, 2023.
Invited talk on "Chemical technologies for precision engineering of proteins and antibodies," Interactions with team Syngene, Syngene Int. Ltd., Biocon SEZ, Biocon Park, Bangalore, Jan 25, 2023.
Invited talk on "Disintegrate theory enabling precision engineering of proteins," Chemical Science 2023 Leaders in the Field Symposium, JNCASR Bangalore, January 22-25, 2023.
Invited talk on "Chemical technologies for precision engineering of proteins and antibodies," Interactions with team Aurigene, Aurigene Oncology, Bangalore, Jan 25, 2023.
Invited talk on "Traceless cysteine-linchpin enables precision engineering of lysine in native proteins," Science society on Clubhouse, Host: Dr. Catarina Cunha, Dept. of Neuroscience, New York University. January 17, 2023. Link for the talk
Invited talk on "Chemical technologies for precision engineering of proteins and antibodies," SERB-DFG Indo-German conclave on a week for young researchers, November 7-10, 2022.
Invited talk on "Chemical technologies for precision engineering of proteins and antibodies," 14th Annual meeting of the Proteomics Society, India and International conference on proteins and proteomics, November 3-5, 2022.
Invited talk on "Human nature inspires precision engineering of proteins," Asian Chemical Biology Initiative (ACBI), Zuri White Sands, Goa, India, September 15-18, 2022.
Invited talk on "Platforms for precisely engineered protein and antibody conjugates," 1st Industry-Academia NOST Conclave, EMBA Hall, SOM, IIT Bombay, September 13-14, 2022.
Future oriented research conferences and exhibitions (FORCE) - Interdisciplinary initiatives in chemical sciences (IICS), Jaypee Palace, Agra, July 28-31, 2022.
Workshop on "Application of NMR spectroscopy to scientific research" at IISER Bhopal, July 10-16, 2022.
CRSI Bronze Medal Talk, 29th CRSI-NCS and CRSI-ACS Symposium, IISER Mohali, July 7-9, 2022.
Medical Science and Engineering Research Center (MEDSER) Workshop, IISER Bhopal, July 1-2, 2022.
Department talk, Department of Chemistry, Rutgers University, USA, June 23, 2022.
Department talk, Institute for Quantitative Biomedicine, Department of Chemistry and Chemical Biology, Emory University, USA, June 20, 2022.
Gordon Research Conference (GRC), Bioorganic Chemistry, Proctor Academy, NH, USA, June 12-17, 2022.
University of Jammu, Azadi ka Amrit Mahotsav, DST and University of Jammu, Feb 27, 2022.
RTCS-OBC-2021, 58th Annual Convention of Chemists (ACC), Indian Chemical Society (ICS), IIT Kharagpur and IISER Kolkata, Dec 22-24, 2021.
Webinar on "Biologics and Novel Therapeutic Modalities." Talk: LDM platform for precision engineering of antibody-drug conjugates. Chemistry Europe: ChemBioChem & ChemMedChem, Dec 13, 2021.
Important Aspects of Organic Chemistry for Sustainable Industrial Development, Department of Chemistry, IIT Patna, October 30, 2021.
Emerging Trends in Medicinal Chemistry, Department of Medicinal Chemistry, NIPER Guwahati, October 29, 2021.
CSIR-CDRI Award Talk, 80th CSIR Foundation Day Celebration, September 27, 2021.
Organic Chemistry Lecture Series, Department of Organic Chemistry, IISc Bangalore, August 27, 2021.
Webinar on "Harnessing the potential of protein engineering to combat diseases." Talk: Protein engineering and directed therapeutics. Tata Institute for Genetics and Society (TIGS) and Biotech Consortium India Limited (BCIL), August 10, 2021.
First Virtual Indo-German Meeting, Talk: Social life of a nucleophile. April 24, 2021.
8th Indian Peptide Symposium, IISc Bangalore, March 24-26, 2021.
iMed.ULisboa Seminar, Pharmacy Faculty, Lisbon University, March 19, 2021.
Colloquium Series, Department of Chemical and Physical Sciences, University of Toronto Mississauga, March 17, 2021.
Colloquium on “Peptide Chemistry,” DRILS Hyderabad, January 8, 2021.
XVI-J-NOST (first virtual) Symposium, IISc Bangalore, Ethics in Science, October 31-November 1, 2020.
IICE Entrepreneurship Talk at IISER Bhopal, Values of entrepreneur filters in the selection of translational research problem, October 23, 2020.
3rd ChemBioChem Virtual Symposium on Chemical Translational Biology, Chemical technologies empowering biologics with precision and modularity, October 14, 2020. (Video)
Chemistry Department Talks, IIT Bombay, Organic chemistry with proteins enabling biology and medicine, September 18, 2020. (Video)
Interactive Lecture at Hansraj College, Delhi University, Science-T: opportunities for chemistry researchers, August 22, 2020.
ACS Science Talks - Virtual Lecture Series, Organic chemistry with proteins creating opportunities in biology and medicine, August 14, 2020. (Video)
CDRI MPC-Friday Seminar, Precision chemistry of native proteins enabling biology and medicine, CDRI Lucknow, July 31, 2020.
International virtual conference, Chemical science for drug discovery and therapy, VNIT Nagpur, July 22-26, 2020.
International virtual conference, Recent advances in organic, medicinal, and biological chemistry, VIT Chennai, July 8-9, 2020.
PAC SERB Webinar, Research project ideation and innovation, How to write an effective proposal: vision, orientation, and direction, SERB New Delhi, July 6, 2020.
RSC Roadshow, JNCASR, Bangalore, November 4, 2019.
SPARC Workshop on Peptide and nanotechnological approaches for novel theranostics, Panjab University, Chandigargh, October 31, 2019.
IIT Kanpur Organic Chemistry Symposium 2019, Hyatt Regency, Lucknow, September 13-14, 2019.
IICE-FITT Worksop, IISER Bhopal, July 24, 2019.
Emerging Trends in Chemistry (IIT Indore 10th year celebration), IIT Indore, July 12-15, 2019.
R&D Center, Thermo Fisher Scientific, Rockford, IL, USA, June 17, 2019.
Department of Chemistry, Boston College, Boston, MA, USA, June 7, 2019.
IIT Bombay Faculty Alumni Network symposium on new and advanced materials and sustainable sciences, Hotel Taj Exotica, Goa, April 6, 2019.
Recent Advances in Organic and Bioorganic Chemistry Symposium (RAOBC), IISER Mohali, March 22-24, 2019.
IIT Bombay Diamond Jubilee Chemistry Symposium, Mumbai, February 25-28, 2019.
INYAS-FoS, Pragati Resort, Hyderabad, December 9-11, 2018.
FICS-2018, Department of Chemistry, IIT Guwahati, December 6-8, 2018.
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, November 27, 2018.
NOST-OCC 2018, XIX Organic Chemistry Conference, Grand Hyatt, Goa, September 6-9, 2018.
CRSI-NSC-23, IISER Bhopal, Bhopal, July 13-15, 2018.
National symposium on bio-active compounds, Khalsa College, Mumbai, June 22, 2018.
Department of Chemistry, IIT Bombay, Mumbai, June 21, 2018.
DST-DBT-SERB Joint Conclave, Jaipur, June 8-10, 2018.
IIRC and Invictus Oncology Private Limited, New Delhi, Mar 31, 2018.
SCIEX Centre for Analytical Science, Gurgaon, Mar 30, 2018.
Indian Peptide Society Symposium, Shankarpur, Kolkata, Feb 22-23, 2018.
Indian Peptide Society Symposium, HBCSE Mumbai, Feb 23-24, 2017.
preICOS Conference, IISER Bhopal, Dec 9, 2016.
IVP Nurturance Program, IISER Bhopal, Dec 2, 2015.
Chemical Frontiers, Goa, August 15-18, 2015.
Emerging Trends in Chemical Sciences, IISER Bhopal, June 25-26, 2015.
TIFR-DCS Seminar, TIFR Mumbai, June 8, 2015.
ABM-2015, IISER Bhopal, Jan 10-11, 2015.
GJIHS-2014, IIT Bombay, Mumbai, Oct 16-17, 2014.
Kaleidoscope - A discussion meeting in Chemistry, The International Centre Goa, Goa, July 3-6, 2014.
NCERT Nurturance Programme, IISER Bhopal, Bhopal, Dec 9-13, 2013.
RSC- West India IYC-Challenge Symposium 2012, Nagpur, Aug 31 - Sept 1, 2012.
37th BSC, BRNS Meeting, BARC, Mumbai, Apr 12, 2012.
Department of Chemistry, IIT Bombay, Dec 19, 2011.
RSC-WIS Students Symposium, Goa, India, October 19-20, 2007.
12th NOST Symposium, Goa, India, July 07-10, 2007.
Session chair
1st Virtual ACES-CRSI Symposium on Chemical Biology, October 5, 2020.
Webinars during CoVID-19
1st ChemBioChem Virtual Symposium, Wiley, May 27, 2020. (Participation)
TRPH-222 Preclinical Development and Interim Phase I Data: Enhancing Clinical Safety and Overcoming ADC Manufacturing Challenges with SMARTag Technology, Catalent Biologics and Triphase, ADC Webinars, May 26, 2020. (Participation)
CHEMBIOSYS 2020, e-Conference, IISER Tirupati, May 25, 2020. (Participation)
Biologics Forum: Tips and Tools for Successful Immunotherapy Bioassay Development, Promega, April 22, 2020. (Participation)
Chemical Probes as Essential Tools for Biological Discovery, Cell Press, April 16, 2020. (Participation)
Conference presentations
Rai, V. Precision chemical tools for protein engineering, Gordon Research Conference - Bioorganic Chemistry, Andover, NH, USA, June 9-14, 2019. (Poster)
Rawale, D. G.; Adusumalli, S. R.; Rai, V. Linchpin directed modification (LDM) platform for precision engineering of proteins, Indian Peptide Symposium, BITS Pilani, Hyderabad, February 28 - March 1, 2019. (Oral and Poster; Best Poster Award)
Rawale, D. G.; Adusumalli, S. R.; Rai, V. Lysine directed single-site labeling of native proteins, IIT Bombay DJCS, Mumbai, February 25-28, 2019. (Poster)
Joshi, P. N.; Rai, V. Single-site labeling of histidine in proteins, I-DEC 2018, IISER Bhopal, December 6-8, 2018. (Oral)
Rawale, D. G.; Adusumalli, S. R.; Rai, V. LDM platform: single-site labeling of native proteins enabled by linchpin directed modification, I-DEC 2018, IISER Bhopal, December 6-8, 2018. (Poster)
Unnikrishnan, V. B.; Purushottam, L.; Rai, V. Gly-tag for metal-free protein purification, I-DEC 2018, IISER Bhopal, December 6-8, 2018. (Poster)
Singudas, R.; Rai, V. Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, and antibodies, I-DEC 2018, IISER Bhopal, December 6-8, 2018. (Poster)
Gupta, M.; Rawale, D. G.; Rai, V. Ordered single-site immobilization of enzymes enabled by linchpin directed modification, I-DEC 2018, IISER Bhopal, December 6-8, 2018. (Poster)
Purushottam, L.; Rai, V. Single-site labeling of proteins enabled by stable hemiaminals, XIIIth J-NOST, BHU, Varanasi, November 9-12, 2017. (Oral)
Reddy, N. C.; Joshi, P. N.; Rai, V. Cysteine directs single-site labeling of native proteins, XIIIth J-NOST, BHU, Varanasi, November 9-12, 2017. (Poster)
Rai, V. Native proteins can be labeled at single-site using chemical methods, UK-India, Newton-Bhabha Fund Researcher Links Workshop, IIT Kanpur, November 6-8, 2017. (Oral)
Purushottam, L.; Rai, V. Single-site labeling of proteins enabled by stable hemiaminals, Interactions, IISER Bhopal, October 7, 2017. (Oral)
Reddy, N. C.; Joshi, P. N.; Rai, V. Cysteine directs single-site labeling of native proteins, Interactions, IISER Bhopal, October 7, 2017. (Poster)
Rai, V. Chemical platforms for single-site labeling of native proteins, RSC-NOST Symposium, Leeds, UK, October 3-6, 2017. (Poster)
Rai, V. Organic chemistry with proteins, XVIII-NOST-OCC, IISER Bhopal, August 24-26, 2017. (Poster)
Rai, V. Single-site chemical modification of un-engineered proteins, Gordon Research Conference - Bioorganic Chemistry, Andover, NH, USA, June 11-16, 2017. (Poster)
Purushottam, L.; Chilamari, M.; Rai, V. Site-selective chemical modification of Lysine in proteins, Inter IISER Chemistry Meeting, IISER Bhopal, January 20-22, 2017. (Poster)
Adusumalli, S. R.; Rawale, D.; Rai, V. Single-site protein modification, Inter IISER Chemistry Meeting, IISER Bhopal, January 20-22, 2017. (Poster)
Adusumalli, S. R.; Rawale, D.; Rai, V. Selectivity of organic reactions in protein modification, PreICOS Conference, IISER Bhopal, December 9-10, 2016. (Poster)
Purushottam, L.; Chilamari, M.; Rai, V. Competition of α-amine and ε-amine in chemical modification of proteins, PreICOS Conference, IISER Bhopal, December 9-10, 2016. (Poster)
Chilamari, M.; Purushottam, L.; Rai, V. Chemo- and site-selective modification of native proteins using aldehyde auto-oxidation and multicomponent approaches, XII J-NOST, CDRI Lucknow, November 24-27, 2016. (Oral)
Rawale, D.; Adusumalli, S. R.; Rai, V. Single-site labeling of native proteins, XII J-NOST, CDRI Lucknow, November 24-27, 2016. (Poster)
Chilamari, M.; Purushottam, L.; Rai, V. Making a single residue react in the protein backbone, Interactions, IISER Bhopal, October 1, 2016. (Oral)
Rawale, D.; Adusumalli, S. R.; Rai, V. Single-site histidine modification of native proteins, Interactions, IISER Bhopal, October 1, 2016. (Poster)
Joshi, P. N.; Purushottam, L.; Das, N.; Mukherjee, S.; Rai, V. XI J-NOST, NISER Bhubaneswar, December 14-17, 2015. (Oral)
Purushottam, L.; Adusumalli, S. R.; Chilamari, M.; Rai, V. XI J-NOST, NISER Bhubaneswar, December 14-17, 2015. (Poster)
Joshi, P. N.; Purushottam, L.; Das, N.; Mukherjee, S.; Rai, V. Interactions, IISER Bhopal, September 5, 2015. (Oral)
Purushottam, L.; Joshi, P.; Rai, V. Interactions, IISER Bhopal, September 5, 2015. (Poster)
Dattatreya, R.; Adusumalli, S. R.; Rai, V. Interactions, IISER Bhopal, September 5, 2015. (Poster)
Adusumalli, S. R.; Rai, V. ISBOC 10, IISER Pune, Pune, Jan 11-15, 2015. (Oral and Poster)
Chilamari, M.; Rai, V. Interactions, IISER Bhopal, August 8, 2014. (Poster)
Adusumalli, S. R.; Singudas, R.; Joshi, P. N.; Rai, V. Interactions, IISER Bhopal, August 8, 2014. (Poster)
Singudas, R.; Adusumalli, S. R.; Joshi, P. N.; Rai, V. Interactions, IISER Bhopal, August 8, 2014. (Oral)
Rai, V.; Hili, R.; Yudin, A. K. Pacifichem 2010, Honolulu, Hawaii, USA, Dec 15 - Dec 20, 2010. (Poster)
Rai, V.; Hili, R.; Yudin, A. K. 93rd CSC Symposium, Toronto, Ontario, Canada, May 29 - June 2, 2010. (Poster)
Zaretsky, S.; Rai, V.; Yudin, A. K. 93rd CSC Symposium, Toronto, Ontario, Canada, May 29 - June 2, 2010.
Jebrail, M. J.; Ng. A.; Rai, V.; Hili, R.; Yudin, A. K.; Wheeler, A. R. 5th Ontario-on-a-Chip Symposium, Toronto, Ontario, Canada, May 20 - May 21, 2010.
Jebrail, M. J.; Ng. A.; Rai, V.; Hili, R.; Yudin, A. K.; Wheeler, A. R. 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, ICC Jeju, Korea, November 1 - November 5, 2009.
Rai, V.; Hili, R.; Yudin, A. K. 92nd CSC Symposium, Hamilton, Ontario, Canada, May 29 - June 3, 2009. (Poster)
Oommen, O. P.; Rai, V.; Namboothiri, I. N. N. 235th ACS National Meeting, ORGN 14, Abstract of Papers,New Orleans, LA, USA, April 6-10, 2008.
Rai, V.; Namboothiri, I. N. N. 9th RSC-CRSI National Symposium in Chemistry, New Delhi, India,February 1-4, 2007. (Poster)
Rai, V.; Namboothiri, I. N. N. 2nd J-NOST Symposium, Jaipur, India, October 12-14, 2006. (Oral)
Rai, V.; Mobin, S. M.; Namboothiri, I. N. N. 231st ACS National Meeting, ORGN 37, Abstract of Papers, Atlanta, GA, USA, March 26-30, 2006. (Oral)
Rai, V.; Namboothiri, I. N. N. National Symposium on Designing the Molecular World through Chemistry, BHU, Varanasi, India, March 24-25, 2006. (Oral)
Rai, V.; Namboothiri, I. N. N. RSC-WIS Students Symposium, NCL, Pune, India, November 25-26, 2005. (Oral and Poster)