The following are the thrust areas of the research in my laboratory:
(i) We correlate the folding of the three human mOMPs VDAC, TOM, SAM, with their function and regulation at the molecular level using in vitro methods in membranes and in vivo cell biology.

(ii) We elicit molecular details of TOM-assisted VDAC import, SAM-assisted VDAC assembly, and consequences of mOMP misfolding in the cell, with correlation to neuronal health.

(iii) We determine how the interactome of mOMPs with the synucleins, A-beta, and tau, governs neuronal survival, and the onset of neurodegeneration.

(iv) We focus on identifying molecular elements of these mOMPs that regulate ROS production and calcium homeostasis, and the underlying correlation to mito-ER homeostasis and ER-stress.

(v) We relate the function of mitochondrial Sam50 with its bacterial counterpart BamA, towards developing next-generation peptidotherapeutics for notorious Gram-negative pathogens.