Balancing anti-viral innate immunity and immune homeostasis

Schematic representation of the regulation of the anti-viral signaling pathway, after sensing by viral products by their cognate pattern recognition receptors (PRRs).

Induction of oncogenesis by HCMV deubiqutinase

HCMV-DUB facilitates deubiquitination of TRAF6, TRAF3, IRAK1, IRF7 and STING to inhibit I-IFN synthesis, which in turn inhibits the expression of several pro-apoptotic genes and induces the expression of anti-apoptotic genes.

Bispecific targeting of the 3′UTR of RIG-I and PB1 by miR-485.

A) Model showing the targeting of RIG-I by miR-485 and the subsequent effects on antiviral responses and the replication of NDV and H5N1 when present at low viral titers. (B) Model showing the targeting of H5N1 PB1 by miR-485 and the subsequent effects on antiviral responses and H5N1 replication at high viral titers.

Regulatory role of IPS1 in cancer ablation

NDV infection and polyIC transfection induce type I IFN-dependent and -independent anticancer activity via the IPS-1, IRF3 and IRF7 axis. The mechanism of the type I IFN relies on high NDV replication, upregulation of TRAIL or downregulation of the BCL2, BIRC3 and PRKCE genes

Organized GIAN course on immunology (17th to 28th Feb.)